Cancer Research and Treatment

Ataxia telangiectasia and Rad3-related (ATR) inhibition by VE-822 potently reversed 5-flourouracil resistance in colorectal cancer cells through targeting DNA damage response

Ainaz Mihanfar, Faezeh Asghari, Maryam Majidinia

Molecular Biology Reports.2024;[Epub] CrossRef

AZD6738 promotes the tumor suppressive effects of trifluridine in colorectal cancer cells

Shinnosuke Harata, Takuya Suzuki, Hiroki Takahashi, Takahisa Hirokawa, Akira Kato, Kaori Watanabe, Takeshi Yanagita, Hajime Ushigome, Kazuyoshi Shiga, Ryo Ogawa, Akira Mitsui, Masahiro Kimura, Yoichi Matsuo, Shuji Takiguchi

Therapeutic Targeting of DNA Replication Stress in Cancer

CRISPR screens guide the way for PARP and ATR inhibitor biomarker discovery

Emily M. Schleicher, George‐Lucian Moldovan

The FEBS Journal.2022; 289(24): 7854. CrossRef

Inhibition of WEE1 Potentiates Sensitivity to PARP Inhibitor in Biliary Tract Cancer

Hye-Rim Seo, Ah-Rong Nam, Ju-Hee Bang, Kyoung-Seok Oh, Jae-Min Kim, Jeesun Yoon, Tae-Yong Kim, Do-Youn Oh

Cancer Research and Treatment.2022; 54(2): 541. CrossRef

DNA Damage Response Inhibitors in Cholangiocarcinoma: Current Progress and Perspectives

Öykü Gönül Geyik, Giulia Anichini, Engin Ulukaya, Fabio Marra, Chiara Raggi

Aging and biliary tract cancers: Epidemiology, molecular biology, and clinical practice

Xiaoling Weng, Xiaoling Song, Rong Shao, Fatao Liu, Yingbin Liu

AZD6738 Inhibits fibrotic response of conjunctival fibroblasts by regulating checkpoint kinase 1/P53 and PI3K/AKT pathways

Longxiang Huang, Qin Ye, Chunlin Lan, Xiaohui Wang, Yihua Zhu

Frontiers in Pharmacology.2022;[Epub] CrossRef

AZD6738 decreases intraocular pressure and inhibits fibrotic response in trabecular meshwork through CHK1/P53 pathway

Longxiang Huang, Zhenni Wei, Xiaohui Wang, Chunlin Lan, Yihua Zhu, Qin Ye

Biochemical Pharmacology.2022; 206: 115340. CrossRef

Synergism of AZD6738, an ATR Inhibitor, in Combination with Belotecan, a Camptothecin Analogue, in Chemotherapy-Resistant Ovarian Cancer

Jin Hur, Mithun Ghosh, Tae Heon Kim, Nahee Park, Kamal Pandey, Young Bin Cho, Sa Deok Hong, Nar Bahadur Katuwal, Minsil Kang, Hee Jung An, Yong Wha Moon

International Journal of Molecular Sciences.2021; 22(3): 1223. CrossRef

ATR inhibition amplifies antitumor effects of olaparib in biliary tract cancer

Ah-Rong Nam, Jeesun Yoon, Mei-Hua Jin, Ju-Hee Bang, Kyoung-Seok Oh, Hye-Rim Seo, Jae-Min Kim, Tae-Yong Kim, Do-Youn Oh

Targeting Cellular DNA Damage Responses in Cancer: An In Vitro-Calibrated Agent-Based Model Simulating Monolayer and Spheroid Treatment Responses to ATR-Inhibiting Drugs

Sara Hamis, James Yates, Mark A. J. Chaplain, Gibin G. Powathil

Bulletin of Mathematical Biology.2021;[Epub] CrossRef

The Role of the Hedgehog Pathway in Cholangiocarcinoma

Giulia Anichini, Laura Carrassa, Barbara Stecca, Fabio Marra, Chiara Raggi

Targeting the DNA damage response: PARP inhibitors and new perspectives in the landscape of cancer treatment

Sofia Genta, Federica Martorana, Anastasios Stathis, Ilaria Colombo

Critical Reviews in Oncology/Hematology.2021; 168: 103539. CrossRef

Inhibition of ATR Increases the Sensitivity to WEE1 Inhibitor in Biliary Tract Cancer

Ah-Rong Nam, Mei-Hua Jin, Ju-Hee Bang, Kyoung-Seok Oh, Hye-Rim Seo, Do-Youn Oh, Yung-Jue Bang

Cancer Research and Treatment.2020; 52(3): 945. CrossRef

Drug resistance in cancer: mechanisms and tackling strategies

Tanweer Haider, Vikas Pandey, Nagma Banjare, Prem N. Gupta, Vandana Soni

Pharmacological Reports.2020; 72(5): 1125. CrossRef

Targeting P53 as a Future Strategy to Overcome Gemcitabine Resistance in Biliary Tract Cancers

Chiao-En Wu, Yi-Ru Pan, Chun-Nan Yeh, John Lunec

ATM Inhibitor Suppresses Gemcitabine-Resistant BTC Growth in a Polymerase θ Deficiency-Dependent Manner

The Cancer Stem Cell Inhibitor Napabucasin (BBI608) Shows General Cytotoxicity in Biliary Tract Cancer Cells and Reduces Cancer Stem Cell Characteristics

Marlena Beyreis, Martin Gaisberger, Martin Jakab, Daniel Neureiter, Katharina Helm, Markus Ritter, Tobias Kiesslich, Christian Mayr

Inhibition of Wee1 sensitizes AML cells to ATR inhibitor VE-822-induced DNA damage and apoptosis

Wenxiu Qi, Xiaohao Xu, Manying Wang, Xiangyan Li, Chaonan Wang, Liping Sun, Daqing Zhao, Liwei Sun

Biochemical Pharmacology.2019; 164: 273. CrossRef