Cancer Research and Treatment

Targeting JAK2/STAT3 for the treatment of cancer: A review on recent advancements in molecular development using structural analysis and SAR investigations

Rupali Kohal, Priya Bisht, Ghanshyam Das Gupta, Sant Kumar Verma

Unraveling the complexity of STAT3 in cancer: molecular understanding and drug discovery

Journal of Experimental & Clinical Cancer Research.2024;[Epub] CrossRef

Hepatocellular Carcinoma: Old and Emerging Therapeutic Targets

Isoalantolactone exerts anti‐melanoma effects via inhibiting PI3K/AKT/mTOR and STAT3 signaling in cell and mouse models

Jun‐Kui Li, Xiao‐Li Jiang, Zhu Zhang, Wen‐Qing Chen, Jun‐Jie Peng, Bin Liu, Pei‐Li Zhu, Ken‐Kin‐Lam Yung

Mechanisms and therapeutic prospect of the JAK-STAT signaling pathway in liver cancer

Molecular and Cellular Biochemistry.2024;[Epub] CrossRef

Prognostic and therapeutic potential of STAT3: Opportunities and challenges in targeting HPV-mediated cervical carcinogenesis

Divya Janjua, Kulbhushan Thakur, Nikita Aggarwal, Apoorva Chaudhary, Joni Yadav, Arun Chhokar, Tanya Tripathi, Udit Joshi, Anna Senrung, Alok Chandra Bharti

Critical Reviews in Oncology/Hematology.2024; 197: 104346. CrossRef

Discovery, Optimization, and Evaluation of Novel N-(Benzimidazol-5-yl)-1,3,4-thiadiazol-2-amine Analogues as Potent STAT3 Inhibitors for Cancer Treatment

Ru Wang, Ting-Ting Du, Wen-Qiang Liu, Yi-Chen Liu, Ya-Dong Yang, Jin-Ping Hu, Ming Ji, Bei-Bei Yang, Li Li, Xiao-Guang Chen

Journal of Medicinal Chemistry.2023; 66(17): 12373. CrossRef

Polyphenols as potential metabolism mechanisms regulators in liver protection and liver cancer prevention

Shuangfeng Li, Shuangshuang Yin, Hui Ding, Yingying Shao, Shiyue Zhou, Weiling Pu, Lifeng Han, Tao Wang, Haiyang Yu

Eupalinolide J Inhibits Cancer Metastasis by Promoting STAT3 Ubiquitin-Dependent Degradation

Hongtao Hu, Haoyang Bai, Lili Huang, Bo Yang, Huajun Zhao

Discovery of a Highly Potent and Orally Bioavailable STAT3 Dual Phosphorylation Inhibitor for Pancreatic Cancer Treatment

Peng He, Aiwu Bian, Ying Miao, Wangrui Jin, Huang Chen, Jia He, Liting Li, Yue Sun, Jiangnan Ye, Mingyao Liu, Zhengfang Yi, Wenbo Zhou, Yihua Chen

Journal of Medicinal Chemistry.2022; 65(22): 15487. CrossRef

Han‐Qi Wang, Qi‐Wen Man, Fang‐Yi Huo, Xin Gao, Hao Lin, Su‐Ran Li, Jing Wang, Fu‐Chuan Su, Lulu Cai,, Yi Shi, Bing Liu,, Lin‐Lin Bu

Systemic Therapy for Hepatocellular Carcinoma: Current Updates and Outlook

Journal of Hepatocellular Carcinoma.2022; Volume 9: 233. CrossRef

Constant Activation of STAT3 Contributes to the Development of Adenomyosis in Females

Takehiro Hiraoka, Yasushi Hirota, Shizu Aikawa, Rei Iida, Chihiro Ishizawa, Tetsuaki Kaku, Tomoyuki Hirata, Yamato Fukui, Shun Akaeda, Mitsunori Matsuo, Ryoko Shimizu-Hirota, Norihiko Takeda, Yutaka Osuga

Biomarker‑driven phase Ib clinical trial of OPB‑111077 in acute myeloid leukemia

Joaquín Martínez‑López, Pau Montesinos, Nieves López‑Muñoz, Rosa Ayala, Pilar Martínez‑Sánchez, Julian Gorrochategui, José Rojas‑Rudilla, Daniel Primo, Juan-Miguel Bergua‑Burgues, María Calbacho, Evelyn Acuña‑Cruz, José Pérez‑Simón, Adolfo De La Fuente, J

Novel STAT3 Inhibitors Targeting STAT3 Dimerization by Binding to the STAT3 SH2 Domain

Yaping Hua, Xing Yuan, Yun-heng Shen, Jinxin Wang, Waqas Azeem, Shuo Yang, Alexandra Gade, Seyed Mohammad Lellahi, Anne Margrete Øyan, Xisong Ke, Wei-dong Zhang, Karl-Henning Kalland

Discovery of a Novel Potent STAT3 Inhibitor HP590 with Dual p-Tyr705/Ser727 Inhibitory Activity for Gastric Cancer Treatment

Peng He, Ying Miao, Yue Sun, Aiwu Bian, Wangrui Jin, Huang Chen, Jiangnan Ye, Jia He, Yangrui Peng, Haijun Gu, Mingyao Liu, Zhengfang Yi, Yihua Chen

Journal of Medicinal Chemistry.2022; 65(19): 12650. CrossRef

STAT3 and Its Targeting Inhibitors in Oral Squamous Cell Carcinoma

NAFLD and HBV interplay - related mechanisms underlying liver disease progression

Evanthia Tourkochristou, Stelios F. Assimakopoulos, Konstantinos Thomopoulos, Markos Marangos, Christos Triantos

An update on investigational therapies that target STAT3 for the treatment of cancer

Matteo Santoni, Francesca Miccini, Alessia Cimadamore, Francesco Piva, Francesco Massari, Liang Cheng, Antonio Lopez-Beltran, Rodolfo Montironi, Nicola Battelli

Expert Opinion on Investigational Drugs.2021; 30(3): 245. CrossRef

Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors

Dingding Gao, Nan Jin, Yixian Fu, Yueyue Zhu, Yujie Wang, Ting Wang, Yuehong Chen, Mingming Zhang, Qiang Xiao, Min Huang, Yingxia Li

European Journal of Medicinal Chemistry.2021; 216: 113333. CrossRef

Journal of Hepatocellular Carcinoma.2021; Volume 8: 223. CrossRef

Manabu Kawada, Masahide Amemiya, Junjiro Yoshida, Tomokazu Ohishi

The Journal of Antibiotics.2021; 74(10): 696. CrossRef

Advances of Targeted Therapy for Hepatocellular Carcinoma

Mitochondrial Plasticity Promotes Resistance to Sorafenib and Vulnerability to STAT3 Inhibition in Human Hepatocellular Carcinoma

Shusil K. Pandit, Giada Sandrini, Jessica Merulla, Valentina Nobili, Xin Wang, Alessia Zangari, Andrea Rinaldi, Dheeraj Shinde, Giuseppina M. Carbone, Carlo V. Catapano

Organic & Biomolecular Chemistry.2020; 18(4): 583. CrossRef

Rewiring Host Signaling: Hepatitis C Virus in Liver Pathogenesis

Alessia Virzì, Armando Andres Roca Suarez, Thomas F. Baumert, Joachim Lupberger

Cold Spring Harbor Perspectives in Medicine.2020; 10(1): a037366. CrossRef

Quinazoline Ligands Induce Cancer Cell Death through Selective STAT3 Inhibition and G-Quadruplex Stabilization

Jan Jamroskovic, Mara Doimo, Karam Chand, Ikenna Obi, Rajendra Kumar, Kristoffer Brännström, Mattias Hedenström, Rabindra Nath Das, Almaz Akhunzianov, Marco Deiana, Kazutoshi Kasho, Sebastian Sulis Sato, Parham L. Pourbozorgi, James E. Mason, Paolo Medini

Journal of the American Chemical Society.2020; 142(6): 2876. CrossRef

Justin Jit Hin Tang, Dexter Kai Hao Thng, Jhin Jieh Lim, Tan Boon Toh

Nature Reviews Clinical Oncology.2020; 17(7): 395. CrossRef

Targeting acute myeloid leukemia stem cells: Current therapies in development and potential strategies with new dimensions

Critical Reviews in Oncology/Hematology.2020; 152: 102993. CrossRef

Manipulation of JAK/STAT Signalling by High-Risk HPVs: Potential Therapeutic Targets for HPV-Associated Malignancies

STAT3 inhibition protects against neuroinflammation and BACE1 upregulation induced by systemic inflammation

Périne Millot, Carine San, Evangeline Bennana, Baptiste Porte, Nicolas Vignal, Jacques Hugon, Claire Paquet, Benoit Hosten, François Mouton-Liger

STAT3 Inhibitor OPB-51602 Is Cytotoxic to Tumor Cells Through Inhibition of Complex I and ROS Induction

Lara Brambilla, Tanaya Lahiri, Michael Cammer, David E. Levy

Systemic Therapy for Hepatocellular Carcinoma: Advances and Hopes

STAT3 as a potential therapeutic target in triple negative breast cancer: a systematic review

Journal of Experimental & Clinical Cancer Research.2019;[Epub] CrossRef

Recent Insights Into the Multiple Pathways Driving Non-alcoholic Steatohepatitis-Derived Hepatocellular Carcinoma

Kazuki Takakura, Tsunekazu Oikawa, Masanori Nakano, Chisato Saeki, Yuichi Torisu, Mikio Kajihara, Masayuki Saruta

Direct Targeting Options for STAT3 and STAT5 in Cancer

Anna Orlova, Christina Wagner, Elvin D. de Araujo, Dávid Bajusz, Heidi A. Neubauer, Marco Herling, Patrick T. Gunning, György M. Keserű, Richard Moriggl