Cancer Research and Treatment

Nano-medicine therapy reprogramming metabolic network of tumour microenvironment: new opportunity for cancer therapies

Xiaojie Zhang, Min An, Juntao Zhang, Yumeng Zhao, Yanhua Liu

Journal of Drug Targeting.2024; 32(3): 241. CrossRef

Purification and characterization of L-arginine deiminase from Penicillium chrysogenum

Hamed M. El-Shora, Nessma A. El-Zawawy, Mohamed A. Abd El-Rheem, Metwally A. Metwally

L-arginase from Streptomyces diastaticus MAM5 as a potential therapeutic agent in breast cancer: Purification, characterization, G1 phase arrest and autophagy induction

Amany A. Hassabo, Mohamed Abdelraof, Rasha M. Allam

International Journal of Biological Macromolecules.2023; 224: 634. CrossRef

Arginine transportation mechanism through cationic amino acid transporter 1: insights from molecular dynamics studies

Journal of Biomolecular Structure and Dynamics.2023; 41(23): 13580. CrossRef

Autophagy and autophagy-related pathways in cancer

Nature Reviews Molecular Cell Biology.2023; 24(8): 560. CrossRef

Amino acids in hematologic malignancies: Current status and future perspective

A role for macrophages under cytokine control in mediating resistance to ADI-PEG20 (pegargiminase) in ASS1-deficient mesothelioma

Melissa M. Phillips, Iuliia Pavlyk, Michael Allen, Essam Ghazaly, Rosalind Cutts, Josephine Carpentier, Joe Scott Berry, Callum Nattress, Shenghui Feng, Gunnel Hallden, Claude Chelala, John Bomalaski, Jeremy Steele, Michael Sheaff, Frances Balkwill, Peter

Pharmacological Reports.2023; 75(3): 570. CrossRef

Immune Checkpoint Inhibitors in Renal Cell Carcinoma: Molecular Basis and Rationale for Their Use in Clinical Practice

Francesco Lasorsa, Nicola Antonio di Meo, Monica Rutigliano, Martina Milella, Matteo Ferro, Savio Domenico Pandolfo, Felice Crocetto, Octavian Sabin Tataru, Riccardo Autorino, Michele Battaglia, Pasquale Ditonno, Giuseppe Lucarelli

Enzyme Cascade with Horseradish Peroxidase Readout for High-Throughput Screening and Engineering of Human Arginase-1

Jaime Fernández De Santaella, Jin Ren, Rosario Vanella, Michael A. Nash

Analytical Chemistry.2023; 95(18): 7150. CrossRef

Human arginase I: a potential broad-spectrum anti-cancer agent

J. Anakha, Yenisetti Rajendra Prasad, Nisha Sharma, Abhay H. Pande

Target Therapy in Malignant Pleural Mesothelioma: Hope or Mirage?

Federica Borea, Marika A. Franczak, Maria Garcia, Matteo Perrino, Nadia Cordua, Ryszard T. Smolenski, Godefridus J. Peters, Rafal Dziadziuszko, Armando Santoro, Paolo A. Zucali, Elisa Giovannetti

International Journal of Molecular Sciences.2023; 24(11): 9165. CrossRef

Inhibition of HSP90 in Driver Oncogene-Defined Lung Adenocarcinoma Cell Lines: Key Proteins Underpinning Therapeutic Efficacy

Ángela Marrugal, Irene Ferrer, Álvaro Quintanal-Villalonga, Laura Ojeda, María Dolores Pastor, Ricardo García-Luján, Amancio Carnero, Luis Paz-Ares, Sonia Molina-Pinelo

International Journal of Molecular Sciences.2023; 24(18): 13830. CrossRef

Chronic Stress Blocks the Endometriosis Immune Response by Metabolic Reprogramming

Chong Lu, Jing Xu, Ke Li, Jing Wang, Yilin Dai, Yiqing Chen, Ranran Chai, Congjian Xu, Yu Kang

International Journal of Molecular Sciences.2023; 25(1): 29. CrossRef

Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma

Danyu Du, Chan Liu, Mengyao Qin, Xiao Zhang, Tao Xi, Shengtao Yuan, Haiping Hao, Jing Xiong

Acta Pharmaceutica Sinica B.2022; 12(2): 558. CrossRef

The effect of l-arginine supplementation and surgical trauma on the frequency of myeloid-derived suppressor cells and T lymphocytes in tumour and blood of colorectal cancer patients

Jarosław Szefel, Tomasz Ślebioda, Jakub Walczak, Wiesław Janusz Kruszewski, Mariusz Szajewski, Maciej Ciesielski, Marcin Stanisławowski, Tomasz Buczek, Sylwia Małgorzewicz, Anna Owczarzak, Ewa Aleksandrowicz-Wrona, Grzegorz Krzykowski

Advances in Medical Sciences.2022; 67(1): 66. CrossRef

Dysbiosis of skin microbiome and gut microbiome in melanoma progression

Chahrazed Mekadim, Helena Kupcova Skalnikova, Jana Cizkova, Veronika Cizkova, Anna Palanova, Vratislav Horak, Jakub Mrazek

Long noncoding RNA LINC01234 promotes hepatocellular carcinoma progression through orchestrating aspartate metabolic reprogramming

Muhua Chen, Chunfeng Zhang, Wei Liu, Xiaojuan Du, Xiaofeng Liu, Baocai Xing

Liver-resident memory T cells: life in lockdown

Seminars in Immunopathology.2022; 44(6): 813. CrossRef

Targeted Arginine Metabolism Therapy: A Dilemma in Glioma Treatment

Xiaoshuang Hou, Sui Chen, Po Zhang, Dongsheng Guo, Baofeng Wang

A virulence factor as a therapeutic: the probiotic Enterococcus faecium SF68 arginine deiminase inhibits innate immune signaling pathways

Fereshteh Ghazisaeedi, Jochen Meens, Bianca Hansche, Sven Maurischat, Peter Schwerk, Ralph Goethe, Lothar H. Wieler, Marcus Fulde, Karsten Tedin

Cell metabolomics study on synergistic anti‐hepatocellular carcinoma effect of Aidi injection combined with doxorubicin

Yanli Wang, Xiaoqing Zhu, Kailiang Wang, Ying Cai, Chunhua Liu, Jie Pan, Jia Sun, Ting Liu, Yong Huang, Yongjun Li, Yuan Lu

Untargeted plasma metabolomics for risk prediction of hepatocellular carcinoma: A prospective study in two Chinese cohorts

Dong Hang, Xiaolin Yang, JiaYi Lu, Chong Shen, Juncheng Dai, Xiangfeng Lu, Guangfu Jin, Zhibin Hu, Dongfeng Gu, Hongxia Ma, Hongbing Shen

International Journal of Cancer.2022; 151(12): 2144. CrossRef

Role of 3'-Deoxy-3'-[18F] Fluorothymidine Positron Emission Tomography-Computed Tomography as a Predictive Biomarker in Argininosuccinate Synthetase 1-Deficient Thoracic Cancers Treated With Pegargiminase

Teresa A. Szyszko, Joel T. Dunn, Melissa M. Phillips, John Bomalaski, Michael T. Sheaff, Steve Ellis, Lucy Pike, Vicky Goh, Gary J.R. Cook, Peter W. Szlosarek

JTO Clinical and Research Reports.2022; 3(9): 100382. CrossRef

Arginine Deprivation in SCLC: Mechanisms and Perspectives for Therapy

Joséphine Carpentier, Iuliia Pavlyk, Uma Mukherjee, Peter E Hall, Peter W Szlosarek

Lung Cancer: Targets and Therapy.2022; Volume 13: 53. CrossRef

J. Anakha, Priyanka S. Kawathe, Sayantap Datta, Snehal Sainath Jawalekar, Uttam Chand Banerjee, Abhay H. Pande

Mitochondrial metabolic determinants of multiple myeloma growth, survival, and therapy efficacy

Enhancement of anti-tumor activity in melanoma using arginine deiminase fused with 30Kc19α protein

Haein Lee, Geunhwa Park, Seulha Kim, Boram Son, Jinmyoung Joo, Hee Ho Park, Tai Hyun Park

Applied Microbiology and Biotechnology.2022; 106(22): 7531. CrossRef

Cationic amino acid transporter-1 (CAT-1) promotes fibroblast-like synoviocyte proliferation and cytokine secretion by taking up L-arginine in rheumatoid arthritis

Ying Lu, Chongbo Hao, Shanshan Yu, Zuan Ma, Xuelian Fu, Mingqing Qin, Menglei Ding, Zengguang Xu, Lieying Fan

Arthritis Research & Therapy.2022;[Epub] CrossRef

Research progress in inducing immunogenic cell death of tumor cells

Unbalanced Glutamine Partitioning between CD8T Cells and Cancer Cells Accompanied by Immune Cell Dysfunction in Hepatocellular Carcinoma

Jianfei Chen, Rui Wang, Zhongliang Liu, Jun Fan, Shenglu Liu, Shunde Tan, Xinkai Li, Bo Li, Xiaoli Yang

Plasma amino acids indicate glioblastoma with ATRX loss

Ernest Jan Bobeff, Dorota Szczesna, Michał Bieńkowski, Karolina Janczar, Malgorzata Chmielewska-Kassassir, Karol Wiśniewski, Wielisław Papierz, Lucyna Alicja Wozniak, Dariusz Jan Jaskólski

Rational design, engineer, and characterization of a novel pegylated single isomer human arginase for arginine depriving anti-cancer treatment

Kuo-Ming Yu, Tammy Pui-shi Pang, Murray Cutler, Min Tian, Lynn Huang, Johnson Yiu-Nam Lau, Sai-Fung Chung, Thomas Wai-hung Lo, Thomas Yun-chung Leung

Dietary intervention as a therapeutic for cancer

Mami Morita, Kei Kudo, Hiroshi Shima, Nobuhiro Tanuma

Harnessing the Co-vulnerabilities of Amino Acid-Restricted Cancers

Pegylated arginine deiminase depletes plasma arginine but maintains tissue arginine availability in young pigs

Mahmoud A. Mohammad, Inka C. Didelija, Barbara Stoll, Trung C. Nguyen, Juan C. Marini

American Journal of Physiology-Endocrinology and Metabolism.2021; 320(3): E641. CrossRef

Targeting the Proline–Glutamine–Asparagine–Arginine Metabolic Axis in Amino Acid Starvation Cancer Therapy

Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy

Mylène Tajan, Marc Hennequart, Eric C. Cheung, Fabio Zani, Andreas K. Hock, Nathalie Legrave, Oliver D. K. Maddocks, Rachel A. Ridgway, Dimitris Athineos, Alejandro Suárez-Bonnet, Robert L. Ludwig, Laura Novellasdemunt, Nikolaos Angelis, Vivian S. W. Li,

Arginine Deiminase Induces Immunogenic Cell Death and Is Enhanced by N-acetylcysteine in Murine MC38 Colorectal Cancer Cells and MDA-MB-231 Human Breast Cancer Cells In Vitro

The cancer metabolic reprogramming and immune response

Longzheng Xia, Linda Oyang, Jinguan Lin, Shiming Tan, Yaqian Han, Nayiyuan Wu, Pin Yi, Lu Tang, Qing Pan, Shan Rao, Jiaxin Liang, Yanyan Tang, Min Su, Xia Luo, Yiqing Yang, Yingrui Shi, Hui Wang, Yujuan Zhou, Qianjin Liao

Metabolomic characterisation of progression and spontaneous regression of melanoma in the melanoma-bearing Libechov minipig model

Martin Kertys, Marian Grendar, Vratislav Horak, Nela Zidekova, Helena Kupcova Skalnikova, Juraj Mokry, Erika Halasova, Jan Strnadel

Phase I study of ADI‐PEG20 plus low‐dose cytarabine for the treatment of acute myeloid leukemia

Hui‐Jen Tsai, Hui‐Hua Hsiao, Ya‐Ting Hsu, Yi‐Chang Liu, Hsiao‐Wen Kao, Ta‐Chih Liu, Shih‐Feng Cho, Xiaoxing Feng, Amanda Johnston, John S. Bomalaski, Ming‐Chung Kuo, Tsai‐Yun Chen

Arginase Therapy Combines Effectively with Immune Checkpoint Blockade or Agonist Anti-OX40 Immunotherapy to Control Tumor Growth

Mark D. Badeaux, Annah S. Rolig, Giulia Agnello, Danlee Enzler, Melissa J. Kasiewicz, Leslie Priddy, Jason F. Wiggins, Alexander Muir, Mark R. Sullivan, Jessica Van Cleef, Christopher Daige, Matthew G. Vander Heiden, Venkatesh Rajamanickam, James E. Woold

Cancer Immunology Research.2021; 9(4): 415. CrossRef

Naturally-occurring spinosyn A and its derivatives function as argininosuccinate synthase activator and tumor inhibitor

Zizheng Zou, Xiyuan Hu, Tiao Luo, Zhengnan Ming, Xiaodan Chen, Li Xia, Wensong Luo, Jijia Li, Na Xu, Ling Chen, Dongsheng Cao, Min Wen, Fanrong Kong, Kunjian Peng, Yuanzhu Xie, Xuan Li, Dayou Ma, Chuanyu Yang, Ceshi Chen, Wenjun Yi, Ousheng Liu, Suyou Liu

Arginine Metabolism and Its Potential in Treatment of Colorectal Cancer

Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef

Aditya A. Mohan, William H. Tomaszewski, Aden P. Haskell-Mendoza, Kelly M. Hotchkiss, Kirit Singh, Jessica L. Reedy, Peter E. Fecci, John H. Sampson, Mustafa Khasraw

Soft Tissue Sarcoma: An Insight on Biomarkers at Molecular, Metabolic and Cellular Level

Serena Pillozzi, Andrea Bernini, Ilaria Palchetti, Olivia Crociani, Lorenzo Antonuzzo, Domenico Campanacci, Guido Scoccianti

Arginine depriving enzymes: applications as emerging therapeutics in cancer treatment

Cancer Chemotherapy and Pharmacology.2021; 88(4): 565. CrossRef

Metabolic Alterations in Preneoplastic Development Revealed by Untargeted Metabolomic Analysis

Henna Myllymäki, Jeanette Astorga Johansson, Estefania Grados Porro, Abigail Elliot, Tessa Moses, Yi Feng

Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef

Dysregulated Alanine as a Potential Predictive Marker of Glioma—An Insight from Untargeted HRMAS-NMR and Machine Learning Data

Safia Firdous, Rizwan Abid, Zubair Nawaz, Faisal Bukhari, Ammar Anwer, Leo L. Cheng, Saima Sadaf

Phase 1, pharmacogenomic, dose‐expansion study of pegargiminase plus pemetrexed and cisplatin in patients with ASS1‐deficient non‐squamous non‐small cell lung cancer

Peter W. Szlosarek, Akhila G. Wimalasingham, Melissa M. Phillips, Peter E. Hall, Pui Ying Chan, John Conibear, Louise Lim, Sukaina Rashid, Jeremy Steele, Paula Wells, Chiung‐Fang Shiu, Chih‐Ling Kuo, Xiaoxing Feng, Amanda Johnston, John Bomalaski, Stephen

Metabolic Reprogramming in the Tumor Microenvironment With Immunocytes and Immune Checkpoints

Fueling T-cell Antitumor Immunity: Amino Acid Metabolism Revisited

Chenfeng Han, Minmin Ge, Ping-Chih Ho, Lianjun Zhang

Cancer Immunology Research.2021; 9(12): 1373. CrossRef

Arginine and Arginases Modulate Metabolism, Tumor Microenvironment and Prostate Cancer Progression

Andreia Matos, Marcos Carvalho, Manuel Bicho, Ricardo Ribeiro

GC/MS-based differential metabolic profiling of human peptic ulcer disease to study Helicobacter pylori-induced metabolic perturbations

GAGANJOT GUPTA, DEEPAK BANSAL, ANSHULA SHARMA, TAWSEEF AHMAD, ATUL SACHDEV, AJAZ AHMAD, HAMED A. EL-SEREHY, BALJINDER KAUR

Lisa Vettore, Rebecca L. Westbrook, Daniel A. Tennant

British Journal of Cancer.2020; 122(2): 150. CrossRef

Preclinical safety and antitumor activity of the arginine-degrading therapeutic enzyme pegzilarginase, a PEGylated, cobalt-substituted recombinant human arginase 1

Giulia Agnello, Susan E. Alters, Scott W. Rowlinson

Tumour metabolism and its unique properties in prostate adenocarcinoma

Nature Reviews Urology.2020; 17(4): 214. CrossRef

Myeloid Cell-Derived Arginase in Cancer Immune Response

Tomasz M. Grzywa, Anna Sosnowska, Paweł Matryba, Zuzanna Rydzynska, Marcin Jasinski, Dominika Nowis, Jakub Golab

Phase II Study of Arginine Deprivation Therapy With Pegargiminase in Patients With Relapsed Sensitive or Refractory Small-cell Lung Cancer

Peter E. Hall, Neal Ready, Amanda Johnston, John S. Bomalaski, Ralph R. Venhaus, Michael Sheaff, Lee Krug, Peter W. Szlosarek

Systems level profiling of arginine starvation reveals MYC and ERK adaptive metabolic reprogramming

Caitlyn B. Brashears, Meltem Barlin, William R. Ehrhardt, Richa Rathore, Matthew Schultze, Shin-Chen Tzeng, Brian A. Van Tine, Jason M. Held

The free amino acid profiles and metabolic biomarkers of predicting the chemotherapeutic response in advanced sarcoma patients

B. Jia, W. Wang, S. Lin, L. Shi, Y. Li, Y. Gu, F. Gao, Y. Qin

Clinical and Translational Oncology.2020; 22(12): 2213. CrossRef

Exercise May Affect Metabolism in Cancer-Related Cognitive Impairment

Modulation of Immuno-biome during Radio-sensitization of Tumors by Glycolytic Inhibitors

Current Medicinal Chemistry.2020; 27(24): 4002. CrossRef

Combinatory Treatment of Canavanine and Arginine Deprivation Efficiently Targets Human Glioblastoma Cells via Pleiotropic Mechanisms

Olena Karatsai, Pavel Shliaha, Ole N. Jensen, Oleh Stasyk, Maria Jolanta Rędowicz

The Janus-like role of proline metabolism in cancer

Lynsey Burke, Inna Guterman, Raquel Palacios Gallego, Robert G. Britton, Daniel Burschowsky, Cristina Tufarelli, Alessandro Rufini

Development of cancer prognostic signature based on pan-cancer proteomics

Weiguo Huang, Jianhui Chen, Wanqing Weng, Yukai Xiang, Hongqi Shi, Yunfeng Shan

Expansion Phase 1 Study of Pegargiminase Plus Pemetrexed and Cisplatin in Patients With Argininosuccinate Synthetase 1–Deficient Mesothelioma: Safety, Efficacy, and Resistance Mechanisms

Peter W. Szlosarek, Melissa M. Phillips, Iuliia Pavlyk, Jeremy Steele, Jonathan Shamash, James Spicer, Sanjeev Kumar, Simon Pacey, Xiaoxing Feng, Amanda Johnston, John Bomalaski, Graeme Moir, Kelvin Lau, Stephen Ellis, Michael Sheaff

JTO Clinical and Research Reports.2020; 1(4): 100093. CrossRef

Selective extracellular arginine deprivation by a single injection of cellular non-uptake arginine deiminase nanocapsules for sustained tumor inhibition

Hongzhao Qi, Yin Wang, Xubo Yuan, Peifeng Li, Lijun Yang

Metabolic Reprogramming in Breast Cancer and Its Therapeutic Implications

Argininosuccinate synthase 1 suppresses cancer cell invasion by inhibiting STAT3 pathway in hepatocellular carcinoma

Xuemei Tao, Qiaozhu Zuo, Haoyu Ruan, Hui Wang, Haojie Jin, Zhuoan Cheng, Yuanyuan Lv, Wenxin Qin, Cun Wang

Acta Biochimica et Biophysica Sinica.2019; 51(3): 263. CrossRef

Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion

Yin Cao, WenWen Ding, JingZi Zhang, Qi Gao, HaoXiang Yang, WangSen Cao, ZhongXia Wang, Lei Fang, RongHui Du

Journal of Proteome Research.2019; 18(5): 2032. CrossRef

Isolation and screening of extracellular anticancer enzymes from halophilic and halotolerant bacteria from different saline environments in Iran

Mahdis Zolfaghar, Mohammad Ali Amoozegar, Khosro Khajeh, Hamid Babavalian, Hamid Tebyanian

Molecular Biology Reports.2019; 46(3): 3275. CrossRef

Arginine Deiminase: Current Understanding and Applications

Mahboubeh Zarei, Mohammad Reza Rahbar, Mohammad Hossein Morowvat, Navid Nezafat, Manica Negahdaripour, Aydin Berenjian, Younes Ghasemi

Recent Patents on Biotechnology.2019; 13(2): 124. CrossRef

The Diverse Functions of Non-Essential Amino Acids in Cancer

Amino Acid Degrading Enzymes and their Application in Cancer Therapy

Vadim S. Pokrovsky, Olga E. Chepikova, Denis Zh. Davydov, Andrey A. Zamyatnin Jr, Alexander N. Lukashev, Elena V. Lukasheva

Current Medicinal Chemistry.2019; 26(3): 446. CrossRef

Yarrow supercritical extract exerts antitumoral properties by targeting lipid metabolism in pancreatic cancer

Lamia Mouhid, Marta Gómez de Cedrón, Elena García-Carrascosa, Guillermo Reglero, Tiziana Fornari, Ana Ramírez de Molina, Olga A. Sukocheva

Aspergillus nidulans thermostable arginine deiminase-Dextran conjugates with enhanced molecular stability, proteolytic resistance, pharmacokinetic properties and anticancer activity

Ashraf S.A. El-Sayed, Ahmed A. Shindia, Azza A. Abou Zeid, Amany M. Yassin, Mahmoud Z. Sitohy, Basel Sitohy

Enzyme and Microbial Technology.2019; 131: 109432. CrossRef

Cationic Amino Acid Transporter-1-Mediated Arginine Uptake Is Essential for Chronic Lymphocytic Leukemia Cell Proliferation and Viability

Anke Werner, Daniel Pieh, Hakim Echchannaoui, Johanna Rupp, Krishnaraj Rajalingam, Matthias Theobald, Ellen I. Closs, Markus Munder

Arginine Starvation and Docetaxel Induce c-Myc–Driven hENT1 Surface Expression to Overcome Gemcitabine Resistance in ASS1-Negative Tumors

Bethany C. Prudner, Richa Rathore, Anthony M. Robinson, Abigail Godec, Samuel F. Chang, William G. Hawkins, Angela C. Hirbe, Brian A. Van Tine

Clinical Cancer Research.2019; 25(16): 5122. CrossRef

Metabolomic profiling identifies distinct phenotypes for ASS1 positive and negative GBM

Lina Mörén, Richard Perryman, Tim Crook, Julia K. Langer, Kevin Oneill, Nelofer Syed, Henrik Antti

Argininosuccinate Synthetase-1 (ASS1) Loss in High-Grade Neuroendocrine Carcinomas of the Urinary Bladder: Implications for Targeted Therapy with ADI-PEG 20

Sounak Gupta, Divya Sahu, John S. Bomalaski, Igor Frank, Stephen A. Boorjian, Prabin Thapa, John C. Cheville, Donna E. Hansel

Arginine: Challenges and opportunities of this two-faced molecule in cancer therapy

Mozhgan Jahani, Fatemeh Noroznezhad, Kamran Mansouri

Biomedicine & Pharmacotherapy.2018; 102: 594. CrossRef

Identification of metabolites in plasma for predicting survival in glioblastoma

Jie Shen, Renduo Song, Tiffany R. Hodges, Amy B. Heimberger, Hua Zhao

Molecular Carcinogenesis.2018; 57(8): 1078. CrossRef

The Citrulline Recycling Pathway Sustains Cardiovascular Function in Arginine-Depleted Healthy Mice, but Cannot Sustain Nitric Oxide Production during Endotoxin Challenge

Yang Yuan, Mahmoud A Mohammad, Ancizar Betancourt, Inka C Didelija, Chandrasekar Yallampalli, Juan C Marini

The Journal of Nutrition.2018; 148(6): 844. CrossRef

Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes

Constantinos Alexandrou, Saif Sattar Al-Aqbi, Jennifer A. Higgins, William Boyle, Ankur Karmokar, Catherine Andreadi, Jin-Li Luo, David A. Moore, Maria Viskaduraki, Matthew Blades, Graeme I. Murray, Lynne M. Howells, Anne Thomas, Karen Brown, Paul N. Chen

Metal ions-induced stability and function of bimetallic human arginase-I, a therapeutically important enzyme

Vineet Sadarangani, Safikur Rahman, Apurba Kumar Sau

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics.2018; 1866(11): 1153. CrossRef

Rewiring urea cycle metabolism in cancer to support anabolism

Rom Keshet, Peter Szlosarek, Arkaitz Carracedo, Ayelet Erez

Nature Reviews Cancer.2018; 18(10): 634. CrossRef

TRAIL stabilization and cancer cell sensitization to its pro-apoptotic activity achieved through genetic fusion with arginine deiminase

Elena Brin, Katherine Wu, Eleanor Dagostino, Mario Meng-Chiang Kuo, Yudou He, Wei-Jong Shia, Li-Chang Chen, Mariusz Stempniak, Richard Hickey, Robert Almassy, Richard Showalter, James Thomson

Decreased argininosuccinate synthetase expression in Thai patients with cholangiocarcinoma and the effects of ADI‑PEG20 treatment in CCA cell lines

Somphon Roeksomtawin, Panida Navasumrit, Somchamai Waraprasit, Varabhorn Parnlob, Thaniya Sricharunrat, Vajarabhongsa Bhudhisawasdi, Niramol Savaraj, Mathuros Ruchirawat

Arginine Deprivation Therapy: Putative Strategy to Eradicate Glioblastoma Cells by Radiosensitization

C. Noreen Hinrichs, Mirjam Ingargiola, Theresa Käubler, Steffen Löck, Achim Temme, Alvaro Köhn-Luque, Andreas Deutsch, Olena Vovk, Oleh Stasyk, Leoni A. Kunz-Schughart

Molecular Cancer Therapeutics.2018; 17(2): 393. CrossRef

Metabolic synthetic lethality in cancer therapy

Biochimica et Biophysica Acta (BBA) - Bioenergetics.2017; 1858(8): 723. CrossRef

Argininosuccinate Synthetase 1 Loss in Invasive Bladder Cancer Regulates Survival through General Control Nonderepressible 2 Kinase–Mediated Eukaryotic Initiation Factor 2α Activity and Is Targetable by Pegylated Arginine Deiminase

Divya Sahu, Sounak Gupta, Andrew M. Hau, Kazufumi Nakashima, Mariah Z. Leivo, Stephen C. Searles, Paul Elson, John S. Bomalaski, Darren E. Casteel, Gerry R. Boss, Donna E. Hansel

The American Journal of Pathology.2017; 187(1): 200. CrossRef

Construction and in vitro evaluation of enzyme nanoreactors based on carboxymethyl chitosan for arginine deprivation in cancer therapy

Tian Zeng, Yi Zhang, Qiongjiao Yan, Zhijun Huang, Ling Zhang, Xiaozhe Yi, Junrong Chen, Guanghua He, Yihua Yin

Drug target identification at the crossroad of neuronal apoptosis and survival

Barbara Maino, Simona Paparone, Cinzia Severini, Maria Teresa Ciotti, Velia D’agata, Pietro Calissano, Sebastiano Cavallaro

Expert Opinion on Drug Discovery.2017; 12(3): 249. CrossRef

Arginine Metabolism in Myeloid Cells Shapes Innate and Adaptive Immunity

Paulo C. Rodriguez, Augusto C. Ochoa, Amir A. Al-Khami

Understanding the Intersections between Metabolism and Cancer Biology

Designing Smart Materials with Recombinant Proteins

Phase 1 Dose-Escalation Study of Pegylated Arginine Deiminase, Cisplatin, and Pemetrexed in Patients With Argininosuccinate Synthetase 1–Deficient Thoracic Cancers

Emma Beddowes, James Spicer, Pui Ying Chan, Ramsay Khadeir, Javier Garcia Corbacho, Dimitra Repana, Jeremy P. Steele, Peter Schmid, Teresa Szyszko, Gary Cook, Monica Diaz, Xiaoxing Feng, Amanda Johnston, Jim Thomson, Michael Sheaff, Bor-Wen Wu, John Bomal

Journal of Clinical Oncology.2017; 35(16): 1778. CrossRef

Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy

The interplay between metabolic remodeling and immune regulation in glioblastoma

Pravin Kesarwani, Shiva Kant, Antony Prabhu, Prakash Chinnaiyan

PRMT7 Interacts with ASS1 and Citrullinemia Mutations Disrupt the Interaction

Mamta Verma, Ramya Chandar M. Charles, Baskar Chakrapani, Mohane Selvaraj Coumar, Gayathri Govindaraju, Arumugam Rajavelu, Sreenivas Chavali, Arunkumar Dhayalan

Journal of Molecular Biology.2017; 429(15): 2278. CrossRef

Technetium-99m complexes ofl-arginine derivatives for targeting amino acid transporters

Maurício Morais, Vera F. C. Ferreira, Flávio Figueira, Filipa Mendes, Paula Raposinho, Isabel Santos, Bruno L. Oliveira, João D. G. Correia

Dalton Transactions.2017; 46(42): 14537. CrossRef

Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors

Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation

Ho-Joon Lee, Mark P. Jedrychowski, Arunachalam Vinayagam, Ning Wu, Ng Shyh-Chang, Yanhui Hu, Chua Min-Wen, Jodene K. Moore, John M. Asara, Costas A. Lyssiotis, Norbert Perrimon, Steven P. Gygi, Lewis C. Cantley, Marc W. Kirschner

A phase 1/1B trial of ADI‐PEG 20 plus nab‐paclitaxel and gemcitabine in patients with advanced pancreatic adenocarcinoma

Maeve A. Lowery, Kenneth H. Yu, David Paul Kelsen, James J. Harding, John S. Bomalaski, Danielle C. Glassman, Christina M. Covington, Robin Brenner, Ellen Hollywood, Adalberto Barba, Amanda Johnston, Kay Chia‐Wei Liu, Xiaoxing Feng, Marinela Capanu, Ghass

A Phase II Study of Arginine Deiminase (ADI-PEG20) in Relapsed/Refractory or Poor-Risk Acute Myeloid Leukemia Patients

Hui-Jen Tsai, Shih Sheng Jiang, Wen-Chun Hung, Gautam Borthakur, Sheng-Fung Lin, Naveen Pemmaraju, Elias Jabbour, John S. Bomalaski, Ya-Ping Chen, Hui-Hua Hsiao, Ming-Chung Wang, Ching-Yuan Kuo, Hung Chang, Su-Peng Yeh, Jorge Cortes, Li-Tzong Chen, Tsai-Y

Cell Chemical Biology.2017; 24(9): 1161. CrossRef

Proliferation of sphere-forming hepatocellular carcinoma cells is suppressed in a medium without glucose and arginine, but with galactose and ornithine

Minoru Tomizawa, Fuminobu Shinozaki, Yasufumi Motoyoshi, Takao Sugiyama, Shigenori Yamamoto, Naoki Ishige

PEGylated arginine deiminase can modulate tumor immune microenvironment by affecting immune checkpoint expression, decreasing regulatory T cell accumulation and inducing tumor T cell infiltration

Elena Brin, Katherine Wu, Hsin-Tze Lu, Yudou He, Zhaoming Dai, Wei He

Gas6/Axl is the sensor of arginine-auxotrophic response in targeted chemotherapy with arginine-depleting agents

W-B Tsai, Y Long, J-R Park, J T Chang, H Liu, J Rodriguez-Canales, N Savaraj, L G Feun, M A Davies, I I Wistuba, M T Kuo

Comparative proteome analysis across non-small cell lung cancer cell lines

Kathrin Grundner-Culemann, J. Nikolaj Dybowski, Martin Klammer, Andreas Tebbe, Christoph Schaab, Henrik Daub

Arginine deprivation induces endoplasmic reticulum stress in human solid cancer cells

Yaroslav Bobak, Yuliya Kurlishchuk, Bozhena Vynnytska-Myronovska, Olesia Grydzuk, Galyna Shuvayeva, Maria J. Redowicz, Leoni A. Kunz-Schughart, Oleh Stasyk

The International Journal of Biochemistry & Cell Biology.2016; 70: 29. CrossRef

Selective Intracellular Delivery of Recombinant Arginine Deiminase (ADI) Using pH-Sensitive Cell Penetrating Peptides To Overcome ADI Resistance in Hypoxic Breast Cancer Cells

Tzyy-Harn Yeh, Yun-Ru Chen, Szu-Ying Chen, Wei-Chiang Shen, David K. Ann, Jennica L. Zaro, Li-Jiuan Shen

Molecular Pharmaceutics.2016; 13(1): 262. CrossRef

Arginine Metabolism in Bacterial Pathogenesis and Cancer Therapy

Lifeng Xiong, Jade Teng, Michael Botelho, Regina Lo, Susanna Lau, Patrick Woo

International Journal of Molecular Sciences.2016; 17(3): 363. CrossRef

Arginine deiminase: recent advances in discovery, crystal structure, and protein engineering for improved properties as an anti-tumor drug

Applied Microbiology and Biotechnology.2016; 100(11): 4747. CrossRef

Arginine dependence of tumor cells: targeting a chink in cancer’s armor

M D Patil, J Bhaumik, S Babykutty, U C Banerjee, D Fukumura

The resistance related to targeted therapy in malignant pleural mesothelioma: Why has not the target been hit yet?

Giuseppe Bronte, Lorena Incorvaia, Sergio Rizzo, Francesco Passiglia, Antonio Galvano, Fabio Rizzo, Christian Rolfo, Daniele Fanale, Angela Listì, Clara Natoli, Viviana Bazan, Antonio Russo

Critical Reviews in Oncology/Hematology.2016; 107: 20. CrossRef

Nature Reviews Cancer.2016; 16(10): 650. CrossRef

Argininosuccinate Synthetase 1 (ASS1) Is a Common Metabolic Marker of Chemosensitivity for Targeted Arginine- and Glutamine-Starvation Therapy

Yan Long, Wen-Bin Tsai, Dajuan Wang, David H. Hawke, Niramol Savaraj, Lynn G. Feun, Mien-Chie Hung, Helen H.W. Chen, Macus Tien Kuo

Tissue metabolic profiling of lymph node metastasis of colorectal cancer assessed by 1H NMR

Hailong Zhang, Liang Qiao, Xiaopeng Li, Yang Wan, Li Yang, Huijuan Wang

Metabolomics profiling in plasma samples from glioma patients correlates with tumor phenotypes

Hua Zhao, Amy B. Heimberger, Zhimin Lu, Xifeng Wu, Tiffany R. Hodges, Renduo Song, Jie Shen

c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma

Yari Ciribilli, Prashant Singh, Alberto Inga, Jürgen Borlak

Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1α, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation

Yan Long, Wen-Bin Tsai, Jeffrey T. Chang, Marcos Estecio, Medhi Wangpaichitr, Naramol Savaraj, Lynn G. Feun, Helen H.W. Chen, Macus Tien Kuo

Co-application of canavanine and irradiation uncouples anticancer potential of arginine deprivation from citrulline availability

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Leucine Metabolism in T Cell Activation: mTOR Signaling and Beyond

Elitsa A Ananieva, Jonathan D Powell, Susan M Hutson

Current Opinion in Clinical Nutrition and Metabolic Care.2015; 18(1): 78. CrossRef

Recombinant arginine‐degrading enzymes in metabolic anticancer therapy and bioanalytics

Oleh V. Stasyk, Yuriy R. Boretsky, Mykhailo V. Gonchar, Andriy A. Sibirny

Cell Biology International.2015; 39(3): 246. CrossRef

Argininosuccinate synthetase (ASS) deficiency in high-grade pulmonary neuroendocrine carcinoma: an opportunity for personalized targeted therapy

Ann E. Walts, John S. Bomalaski, Delma Ines, Sandra Orsulic

Journal of Cancer Research and Clinical Oncology.2015; 141(8): 1363. CrossRef

Expression profile and down-regulation of argininosuccinate synthetase in hepatocellular carcinoma in a transgenic mouse model

Shih-Chang Shiue, Miao-Zeng Huang, Ting-Fen Tsai, Alice Chien Chang, Kong Bung Choo, Chiu-Jung Huang, Tsung-Sheng Su

Journal of Biomedical Science.2015;[Epub] CrossRef

Perioperative dynamics and significance of amino acid profiles in patients with cancer

Yu Gu, Tianxiang Chen, Suzhen Fu, Xin Sun, Lingyan Wang, Jian Wang, Yingfeng Lu, Songming Ding, Guodong Ruan, Lisong Teng, Min Wang

Journal of Translational Medicine.2015;[Epub] CrossRef

Nitric oxide synthase in innate and adaptive immunity: an update

Searching for targets for the systemic therapy of mesothelioma

R.A. Stahel, W. Weder, E. Felley-Bosco, U. Petrausch, A. Curioni-Fontecedro, I. Schmitt-Opitz, S. Peters

Targeting arginine metabolism pathway to treat arginine-dependent cancers

Arginine deprivation by arginine deiminase ofStreptococcus pyogenescontrols primary glioblastoma growthin vitroandin vivo

Tomas Fiedler, Madlen Strauss, Silvio Hering, Ulrike Redanz, Doreen William, Yvonne Rosche, Carl Friedrich Classen, Bernd Kreikemeyer, Michael Linnebacher, Claudia Maletzki

Cancer Biology & Therapy.2015; 16(7): 1047. CrossRef

Arginine deprivation using pegylated arginine deiminase has activity against primary acute myeloid leukemia cells in vivo

Farideh Miraki-Moud, Essam Ghazaly, Linda Ariza-McNaughton, Katharine A. Hodby, Andrew Clear, Fernando Anjos-Afonso, Konstantinos Liapis, Marianne Grantham, Fareeda Sohrabi, Jamie Cavenagh, John S. Bomalaski, John G. Gribben, Peter W. Szlosarek, Dominique

Therapeutic interventions to disrupt the protein synthetic machinery in melanoma

Pigment Cell & Melanoma Research.2015; 28(5): 501. CrossRef

Research into cancer metabolomics: Towards a clinical metamorphosis

Orianne Olivares, J. Henry M. Däbritz, Ayala King, Eyal Gottlieb, Christina Halsey

Seminars in Cell & Developmental Biology.2015; 43: 52. CrossRef

Argininosuccinate lyase is a potential therapeutic target in breast cancer

HAU-LUN HUANG, WEI-CHING CHEN, HUI-PING HSU, CHIEN-YU CHO, YU-HSUAN HUNG, CHIH-YANG WANG, MING-DERG LAI

Arginine Depletion by Arginine Deiminase Does Not Affect Whole Protein Metabolism or Muscle Fractional Protein Synthesis Rate in Mice

Targeting amino acid metabolism in cancer growth and anti-tumor immune response

World Journal of Biological Chemistry.2015; 6(4): 281. CrossRef

Targeting cancer metabolism at the plasma membrane by limiting amino acid access through SLC6A14

l-Arginine Depletion Blunts Antitumor T-cell Responses by Inducing Myeloid-Derived Suppressor Cells

Matthew Fletcher, Maria E. Ramirez, Rosa A. Sierra, Patrick Raber, Paul Thevenot, Amir A. Al-Khami, Dulfary Sanchez-Pino, Claudia Hernandez, Dorota D. Wyczechowska, Augusto C. Ochoa, Paulo C. Rodriguez

A transgenic approach to study argininosuccinate synthetase gene expression

Journal of Biomedical Science.2014;[Epub] CrossRef

The role of arginine and the modified arginine deiminase enzyme ADI-PEG 20 in cancer therapy with special emphasis on Phase I/II clinical trials

Anna Synakiewicz, Teresa Stachowicz-Stencel, Elzbieta Adamkiewicz-Drozynska

Expert Opinion on Investigational Drugs.2014; 23(11): 1517. CrossRef

Arginine deprivation and autophagic cell death in cancer

Proceedings of the National Academy of Sciences.2014; 111(39): 14015. CrossRef

Cellular Serpents and Dreaming Spires: New Frontiers in Arginine and Pyrimidine Biology

Journal of Genetics and Genomics.2014; 41(10): 561. CrossRef

Pegylated arginine deiminase synergistically increases the cytotoxicity of gemcitabine in human pancreatic cancer

Rouzbeh Daylami, Diego J Muilenburg, Subbulakshmi Virudachalam, Richard J Bold

Journal of Experimental & Clinical Cancer Research.2014;[Epub] CrossRef

Down-regulation of argininosuccinate synthetase is associated with cisplatin resistance in hepatocellular carcinoma cell lines: implications for PEGylated arginine deiminase combination therapy

Jennifer A McAlpine, Hsin-Tze Lu, Katherine C Wu, Susan K Knowles, James A Thomson