Cancer Research and Treatment

Leveraging CRISPR/Cas12 signal amplifier to sensitive detection of apurinic/apyrimidinic endonuclease 1 and high-throughput inhibitor screening

Sheng Ding, Yi Yuan, Juan Dong, Feng Du, Xin Cui, Zheng Shi, Zhuo Tang

Analytica Chimica Acta.2024; 1291: 342212. CrossRef

Protective effect of secretory APE1/Ref‐1 on doxorubicin‐induced cardiotoxicity via suppression of ROS and p53 pathway

Soo Yeon An, Seon‐Ah Jin, Hee Jeong Seo, Yu Ran Lee, Sungmin Kim, Byeong Hwa Jeon, Jin‐Ok Jeong

ESC Heart Failure.2024; 11(2): 1182. CrossRef

Enhancing APE1 detection through apurinic/apyrimidinic site inhibition of DNA polymerase: an innovative, highly sensitive approach

Zhijun Liu, Bei Yan, Huan Liu, Xiao Liu, Xianjin Xiao, Zhihao Ming

Chemical Communications.2024; 60(35): 4695. CrossRef

The DNA-repair protein APE1 participates with hnRNPA2B1 to motif-enriched and prognostic miRNA secretion

Giovanna Mangiapane, Michela Notarangelo, Giulia Canarutto, Fabrizio Fabbiano, Emiliano Dalla, Monica Degrassi, Giulia Antoniali, Nicolò Gualandi, Veronica De Sanctis, Silvano Piazza, Vito Giuseppe D’Agostino, Gianluca Tell

A multifunctional DNA repair enzyme and magnetic dual-triggered theranostic nanosystem for intelligent drug delivery

Zhuo Peng, Keni Ning, Xiaoyan Tang, Ruikai He, Dong-Yang Zhang, Yan Ma, Shixia Guan, Junqiu Zhai

Materials & Design.2023; 226: 111611. CrossRef

Electrochemical biosensor based on bipedal DNA walker for highly sensitive amplification detection of apurinic/apyrimidinic endonuclease 1

Xingcong Wang, Jinting Meng, Haoping Zhang, Jingyan Mou, Jinping Xiong, Hong Wang, Xin Su, Yingwei Zhang

Sensors and Actuators B: Chemical.2023; 381: 133425. CrossRef

An AND‐Gate DNA Nanodevice for Dual Protein‐Mediated, Tumor‐Specific Imaging

Chinese Journal of Chemistry.2023; 41(12): 1437. CrossRef

Revisiting Two Decades of Research Focused on Targeting APE1 for Cancer Therapy: The Pros and Cons

Matilde Clarissa Malfatti, Alessia Bellina, Giulia Antoniali, Gianluca Tell

Elevated Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Effector Factor-1 Levels in Refractory Kawasaki Disease

Yu-Ran Lee, Eun Young Bae, Hong Ryang Kil, Byeong-Hwa Jeon, Geena Kim

Mechanistic decoupling of exonuclease III multifunctionality into AP endonuclease and exonuclease activities at the single-residue level

Donghun Lee, Sanghoon Oh, HyeokJin Cho, Jungmin Yoo, Gwangrog Lee

Nucleic Acids Research.2022; 50(4): 2211. CrossRef

APE1/Ref-1 Role in Inflammation and Immune Response

Thais Teixeira Oliveira, Leonam Gomes Coutinho, Laysa Ohana Alves de Oliveira, Ana Rafaela de Souza Timoteo, Guilherme Cavalcanti Farias, Lucymara Fassarella Agnez-Lima

Frontiers in Immunology.2022;[Epub] CrossRef

“RESET” Effect: Random Extending Sequences Enhance the Trans-Cleavage Activity of CRISPR/Cas12a

Jia-Yi Ma, Si-Yuan Wang, Yi-Chen Du, Dong-Xia Wang, An-Na Tang, Jing Wang, De-Ming Kong

Analytical Chemistry.2022; 94(22): 8050. CrossRef

A dual-functional fluorescent biosensor based on enzyme-involved catalytic hairpin assembly for the detection of APE1 and miRNA-21

Incorporating quaternary mesoporous nanospheres and DNA stochastic nanowalkers into a signal amplified switch: A highly sensitive electrochemical assay for APE1

Qingsong Wei, Zhisheng Teng, Xuelian Luo, Yuxin Yang, Yuxia Ren, Wenbin Liang, Ying Zhuo, Zhaoyang Zhong

Sensors and Actuators B: Chemical.2022; 370: 132386. CrossRef

Identification and Quantification of Apurinic/Apyrimidinic Endonuclease 1 in Human Peripheral Blood Leukocytes by Liquid Chromatography/Isotope-Dilution High Resolution Mass Spectrometry

Journal of Basic and Clinical Health Sciences.2022; 6(3): 851. CrossRef

The multifunctional APE1 DNA repair–redox signaling protein as a drug target in human disease

Rachel A. Caston, Silpa Gampala, Lee Armstrong, Richard A. Messmann, Melissa L. Fishel, Mark R. Kelley

Drug Discovery Today.2021; 26(1): 218. CrossRef

A DNA structure-mediated fluorescent biosensor for apurinic/apyrimidinic endonuclease 1 activity detection with ultra-high sensitivity and selectivity

Yuqiang Hu, Zhen Zhang, Weicong Ye, Wei Zhang, Minghao Hu, Wenqian Yuan, Hongbo Wang, Xianjin Xiao, Tongbo Wu

Sensors and Actuators B: Chemical.2021; 330: 129332. CrossRef

Spectroscopic sensing and quantification of AP-endonucleases using fluorescence-enhancement by cis–trans isomerization of cyanine dyes

JunHo Cho, Sanghoon Oh, DongHun Lee, Jae Won Han, Jungmin Yoo, Daeho Park, Gwangrog Lee

Enzymatically active apurinic/apyrimidinic endodeoxyribonuclease 1 is released by mammalian cells through exosomes

Giovanna Mangiapane, Isabella Parolini, Kristel Conte, Matilde Clarissa Malfatti, Jessica Corsi, Massimo Sanchez, Agostina Pietrantoni, Vito G. D’Agostino, Gianluca Tell

Journal of Biological Chemistry.2021; 296: 100569. CrossRef

APE1 and SSRP1 is overexpressed in muscle invasive bladder cancer and associated with poor survival

Heyu Song, Jiping Zeng, Subodh Lele, Chad A. LaGrange, Kishor K. Bhakat

Cephalomannine inhibits hypoxia-induced cellular function via the suppression of APEX1/HIF-1α interaction in lung cancer

Asmat Ullah, Sze Wei Leong, Jingjing Wang, Qing Wu, Mohsin Ahmad Ghauri, Ammar Sarwar, Qi Su, Yanmin Zhang

A Cooperatively Activatable, DNA‐based Fluorescent Reporter for Imaging of Correlated Enzymatic Activities

Angewandte Chemie.2021; 133(27): 15013. CrossRef

A Cooperatively Activatable, DNA‐based Fluorescent Reporter for Imaging of Correlated Enzymatic Activities

Angewandte Chemie International Edition.2021; 60(27): 14887. CrossRef

Blood-based protein biomarkers in bladder urothelial tumors

Rubén López-Cortés, Benito Blanco Gómez, Sergio Vázquez-Estévez, Daniel Pérez-Fentes, Cristina Núñez

Journal of Proteomics.2021; 247: 104329. CrossRef

Changes in the Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1(APE1/Ref-1) Level during Cancer Surgery: An Observational Study

Yumin Jo, Yeojung Kim, Eunhye Park, Yuran Lee, Jiyeon Kim, Minwoong Kang, Jaesung Lim, Insang Song, Chaeseong Lim, Byeonghwa Jeon

Nucleases as molecular targets for cancer diagnosis

Graphene Quantum Dot-Based Nanocomposites for Diagnosing Cancer Biomarker APE1 in Living Cells

Hao Zhang, Sai Ba, Zhaoqi Yang, Tianxiang Wang, Jasmine Yiqin Lee, Tianhu Li, Fangwei Shao

ACS Applied Materials & Interfaces.2020; 12(12): 13634. CrossRef

The Biological Role of Apurinic/Apyrimidinic Endonuclease1/Redox Factor-1 as a Therapeutic Target for Vascular Inflammation and as a Serologic Biomarker

Non-muscle invasive bladder cancer tissues have increased base excision repair capacity

Berna Somuncu, Selcuk Keskin, Fatma Merve Antmen, Yesim Saglican, Aysegul Ekmekcioglu, Tugce Ertuzun, Mustafa Bilal Tuna, Can Obek, David M. Wilson, Umit Ince, Ali Riza Kural, Meltem Muftuoglu

Correlation of APE1 with VEGFA and CD163+ macrophage infiltration in bladder cancer and their prognostic significance

Lin-Ang Wang, Bo Yang, Tang Tang, Yuxin Yang, Dianzheng Zhang, Hualiang Xiao, Jing Xu, Luofu Wang, Li Lin, Jun Jiang

Oncology Letters.2020; 20(3): 2881. CrossRef

Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 Could Serve as a Potential Serological Biomarker for the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma

Journal of Oral and Maxillofacial Surgery.2019; 77(4): 859. CrossRef

The extracellular role of Ref-1 as anti-inflammatory function in lipopolysaccharide-induced septic mice

Hee Kyoung Joo, Yu Ran Lee, Eun-Ok Lee, Myoung Soo Park, Sunga Choi, Cuk-Seong Kim, Jin-Bong Park, Byeong Hwa Jeon

Free Radical Biology and Medicine.2019; 139: 16. CrossRef

ATP Binding Cassette Transporter A1 is Involved in Extracellular Secretion of Acetylated APE1/Ref-1

Yu Ran Lee, Hee Kyoung Joo, Eun Ok Lee, Hyun Sil Cho, Sunga Choi, Cuk-Seong Kim, Byeong Hwa Jeon

International Journal of Molecular Sciences.2019; 20(13): 3178. CrossRef

An electrochemical biosensor integrating immunoassay and enzyme activity analysis for accurate detection of active human apurinic/apyrimidinic endonuclease 1

Mengru Zhou, Chang Feng, Dongsheng Mao, Shiqi Yang, Lingjie Ren, Guifang Chen, Xiaoli Zhu

Biosensors and Bioelectronics.2019; 142: 111558. CrossRef

APEX1 Expression as a Potential Diagnostic Biomarker of Clear Cell Renal Cell Carcinoma and Hepatobiliary Carcinomas

Ji-Myung Kim, Min-Kyung Yeo, Jae Lim, In-Sang Song, Kwangsik Chun, Kyung-Hee Kim

Journal of Clinical Medicine.2019; 8(8): 1151. CrossRef

Serum Apurinic/Apyrimidinic Endodeoxyribonuclease 1 (APEX1) Level as a Potential Biomarker of Cholangiocarcinoma

Doungdean Tummanatsakun, Tanakorn Proungvitaya, Sittiruk Roytrakul, Temduang Limpaiboon, Sopit Wongkham, Chaisiri Wongkham, Atit Silsirivanit, Ongart Somintara, Sakkarn Sangkhamanon, Siriporn Proungvitaya

Serum AP-endonuclease 1 (sAPE1) as novel biomarker for hepatocellular carcinoma

Devis Pascut, Caecilia Hapsari Ceriapuri Sukowati, Giulia Antoniali, Giovanna Mangiapane, Silvia Burra, Luca Giovanni Mascaretti, Matteo Rossano Buonocore, Lory Saveria Crocè, Claudio Tiribelli, Gianluca Tell

Apurinic/apyrimidinic endonuclease/redox factor 1 (APE1) alleviates myocardial hypoxia‑reoxygenation injury by inhibiting oxidative stress and ameliorating mitochondrial dysfunction

Jie Hao, Hong Du, Fan Liu, Jing‑Chao Lu, Xiu‑Chun Yang, Wei Cui

Experimental and Therapeutic Medicine.2019;[Epub] CrossRef

Antitumor Activity and Mechanistic Characterization of APE1/Ref-1 Inhibitors in Bladder Cancer

Melissa L. Fishel, Hanyu Xia, Jack McGeown, David W. McIlwain, May Elbanna, Ariel A. Craft, Hristos Z. Kaimakliotis, George E. Sandusky, Chi Zhang, Roberto Pili, Mark R. Kelley, Travis J. Jerde

Molecular Cancer Therapeutics.2019; 18(11): 1947. CrossRef

Therapeutic positioning of secretory acetylated APE1/Ref-1 requirement for suppression of tumor growth in triple-negative breast cancer in vivo

Yu Ran Lee, Myoung Soo Park, Hee Kyoung Joo, Ki Mo Kim, Jeryong Kim, Byeong Hwa Jeon, Sunga Choi

Differential expression of APE1 in hepatocellular carcinoma and the effects on proliferation and apoptosis of cancer cells

Zhipeng Sun, Yubing Zhu, Aminbuhe, Qing Fan, Jirun Peng, Nengwei Zhang

BioScience Trends.2018; 12(5): 456. CrossRef

DNA base excision repair proteins APE‐1 and XRCC‐1 are overexpressed in oral tongue squamous cell carcinoma

Thalita Santana, Melka Coêlho Sá, Edilmar de Moura Santos, Hébel Cavalcanti Galvão, Ricardo D. Coletta, Roseana de Almeida Freitas

Journal of Oral Pathology & Medicine.2017; 46(7): 496. CrossRef

A graphene oxide-based tool-kit capable of characterizing and classifying exonuclease activities

Jayeon Song, Vo Minh Hoa, Jungmin Yoo, Sanghoon Oh, Hyeryeon Im, Daeho Park, Gwangrog Lee

Apurinic/apyrimidinic endonuclease 1 (APE1) is overexpressed in malignant transformation of salivary gland pleomorphic adenoma

Leorik Pereira Silva, Thalita Santana, Bruno Tavares Sedassari, Suzana Machado de Sousa, Ana Paula Veras Sobral, Roseana de Almeida Freitas, Carlos Augusto Galvão Barboza, Lélia Batista de Souza

European Archives of Oto-Rhino-Laryngology.2017; 274(8): 3203. CrossRef

Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic

Fenil Shah, Derek Logsdon, Richard A. Messmann, Jill C. Fehrenbacher, Melissa L. Fishel, Mark R. Kelley

npj Precision Oncology.2017;[Epub] CrossRef

APE1/Ref‐1 knockdown in pancreatic ductal adenocarcinoma – characterizing gene expression changes and identifying novel pathways using single‐cell RNA sequencing

Fenil Shah, Emery Goossens, Nadia M. Atallah, Michelle Grimard, Mark R. Kelley, Melissa L. Fishel

Molecular Oncology.2017; 11(12): 1711. CrossRef

Elevation of Serum APE1/Ref-1 in Experimental Murine Myocarditis

Seon-Ah Jin, Byung-Kwan Lim, Hee Seo, Sun Kim, Kye Ahn, Byeong Jeon, Jin-Ok Jeong

International Journal of Molecular Sciences.2017; 18(12): 2664. CrossRef

APE1 overexpression is associated with poor survival in patients with solid tumors: a meta-analysis

Chun-Ling Yuan, Fan He, Jia-Zhou Ye, Hui-Ni Wu, Jin-Yan Zhang, Zhi-Hui Liu, Yong-Qiang Li, Xiao-Ling Luo, Yan Lin, Rong Liang

Urinary APE1/Ref-1: A Potential Bladder Cancer Biomarker

Sunga Choi, Ju Hyun Shin, Yu Ran Lee, Hee Kyoung Joo, Ki Hak Song, Yong Gil Na, Seok Jong Chang, Jae Sung Lim, Byeong Hwa Jeon

Secreted APE1/Ref-1 inhibits TNF-α-stimulated endothelial inflammation via thiol-disulfide exchange in TNF receptor

Myoung Soo Park, Sunga Choi, Yu Ran Lee, Hee Kyoung Joo, Gun Kang, Cuk-Seong Kim, Soo Jin Kim, Sang Do Lee, Byeong Hwa Jeon

Altered Secretory Activity of APE1/Ref-1 D148E Variants Identified in Human Patients With Bladder Cancer

Yu Ran Lee, Jae Sung Lim, Ju Hyun Shin, Sunga Choi, Hee Kyoung Joo, Byeong Hwa Jeon

International Neurourology Journal.2016; 20(Suppl 1): S30. CrossRef

Dynamic Regulation of APE1/Ref-1 as a Therapeutic Target Protein

Chonnam Medical Journal.2016; 52(2): 75. CrossRef

Serum APE1 as a predictive marker for platinum-based chemotherapy of non-small cell lung cancer patients

Shiheng Zhang, Le He, Nan Dai, Wei Guan, Jinlu Shan, Xueqin Yang, Zhaoyang Zhong, Yi Qing, Feng Jin, Chuan Chen, Yuxin Yang, Hongyi Wang, Laura Baugh, Gianluca Tell, David M. Wilson, Mengxia Li, Dong Wang